Note: Since parathyroid hormone (PTH) is required for the conversion of vitamin D (ergocalciferol or cholecalciferol) to the active metabolite of vitamin D (1,25-dihydroxyvitamin D), alternative vitamin D preparations not dependent on this conversion (eg, alfacalcidol, calcitriol) are recommended for routine use (Endocrine Society ). Hypoparathyroidism: Treatment of hypoparathyroidism. Inactive until hydroxylated hepatically to 25-hydroxyvitamin D then renally to the active metabolite 1,25-dihydroxyvitamin D (calcitriol) Excretionġ0 to 24 hours Maximum effect: ~1 month following daily doses Half-Life EliminationĬirculating: 25(OH)D: 2 to 3 weeks 1,25-dihydroxyvitamin D ~4 hours Use: Labeled Indicationsĭietary supplement: For use as a vitamin D supplement. Pharmacokinetics/Pharmacodynamics AbsorptionĪbsorbed in the small intestine fat soluble requires bile (IOM 2011) Metabolism The active metabolite, 1,25-dihydroxyvitamin D (calcitriol), stimulates calcium and phosphate absorption from the small intestine, promotes secretion of calcium from bone to blood promotes renal tubule phosphate resorption. Ergocalciferol (vitamin D 2) is a provitamin.
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